Bovine lactoferrin activity against Chikungunya and Zika viruses

Bovine lactoferrin activity against Chikungunya and Zika viruses.

Chikungunya (CHIKV) and Zika (ZIKV) viruses are arboviruses which have recently broken their sylvatic isolation and gone on to spread rampantly among humans in some urban areas of the world, especially in Latin America. Given the lack of effective interventions against such viruses, the aim of this work was to evaluate the antiviral potential of bovine lactoferrin (bLf) in their infections. Thr...

Integrated Human-Virus Metabolic Modelling Predicts Host-Based Antiviral Targets Against Chikungunya, Dengue and Zika Viruses

Antibacterial activity in bovine lactoferrin-derived peptides.

Several peptides sharing high sequence homology with lactoferricin B (Lf-cin B) were generated from bovine lactoferrin (Lf) with recombinant chymosin. Two peptides were copurified, one identical to Lf-cin B and another differing from Lf-cin B by the inclusion of a C-terminal alanine (lactoferricin). Two other peptides were copurified from chymosin-hydrolyzed Lf, one differing from Lf-cin B by t...

Neurological manifestations of Chikungunya and Zika infections Manifestações neurológicas das infecções pelos vírus Zika e Chikungunya

The pandemic of Chikungunya virus (CHIKV) and Zika virus (ZIKV) infection throughout South and Central America is the most important epidemiological occurrence nowadays. High temperatures rates, vector abundance, and inability to control it makes Latin America a high-risk area for the establishment and spread of arbovirus diseases and, as a consequence, their neurological complications. This ar...

Single-Reaction Multiplex Reverse Transcription PCR for Detection of Zika, Chikungunya, and Dengue Viruses

Clinical manifestations of Zika virus, chikungunya virus, and dengue virus infections can be similar. To improve virus detection, streamline molecular workflow, and decrease test costs, we developed and evaluated a multiplex real-time reverse transcription PCR for these viruses.